منابع مشابه
[Ex vivo veritas].
427 LE P OI NT D E VU E DE S IR IU S FO RU M Ayant eu le privilège d’assister au Symposium International sur les cellules ES humaines (FISH-ESC) organisé par Marc Peschanski (Genocentre d’Évry, 31 janvier-2 février 2008) (➜), je voudrais le replacer dans le contexte de la révolution de la biologie moléculaire et de son impact médical. La plupart des gènes de maladies humaines et leurs mutations...
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Specific genotoxicity of solid particles are discussed by using three different examples. Carcinogenic asbestos fibres have primary genotoxic effects as well, that can be studied in in vitro studies. Nevertheless, demonstration of their mesothelioma inducing effect is only possible in in vivo studies. Their carrier function seems to be essential for the biological activity. Carbon nanotubes do ...
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Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. Progress has now been made in defining the signaling pathways, transcriptional networks, and ...
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For several years, our group has been studying the in vivo role of adrenergic and cholinergic mechanisms in the immune-neuroendocrine dialogue in the rat model. The main results of these studies can be summarized as follows: (1) exogenous or endogenous catecholamines suppress PBL functions through alpha-2-receptor-mediated mechanisms, lymphocytes of the spleen are resistant to adrenergic in viv...
متن کاملSpecial Feature T cell activation: in vivo veritas
Phenotypic changes in CD4 + T cells undergoing antigen-dependent activation were compared in vivo and in vitro . The most obvious difference was in expression of CD25, the alpha chain of the high affinity receptor for IL-2. High level expression of CD25 in vivo is restricted to a small fraction of the cells at the leading edge of the cell division profile, whereas all activated cells express hi...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2008
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/2008244427